It is located on the promontory of the historical peninsula in İstanbul which overlooks both the Marmara Sea and the Bosphorus. The walls enclosing the palace grounds, the main gate on the land side and the first buildings were constructed during the time of Fatih Sultan Mehmet (the Conqueror) (1451 - 81). The palace has taken its present layout with the addition of new structures in the later centuries. Topkapı Palace was the official residence of the Ottoman Sultans, starting with Fatih Sultan Mehmet until 1856, when Abdülmecid moved to the Dolmabahçe palace, functioned as the administrative center of the state. The Enderun section also gained importance as a school.

The main exterior gate of the Topkapı Palace is the Imperial Gate (Bab-ı Hümayun) which opens up to the Ayasofya Square. This gate leads to a garden known as the First Court. This court has the Aya Irini Church which was once used as an ammunition depot and behind the Church there is the mint. In the past various pavillions allocated to different services of the palace were located in the First Court. In later years these have been replaced with public buildings and schools. Some of these are still existing. At the end of the 19th century Archeology Museum and School of Fine Arts (now Oriental Works Museum) were built in the large garden which is to the northwest of the First Court.
The oldest structure in this section is the Çinili Köşk built by Fatih, which is now used as the Museum of Turkish Tiles and Ceramics. On the walls of this outer garden facing Bab-ı ali (the Imperial Gate), there is Alay Köşkü (procession Pavillion) where the Sultans used to watch the marching ceremonies. A section of the outer garden was planned by the municipality at the beginning of the 20th century and opened to the public.Known today as the Gülhane Park, the enterance has one of the largerst gates of the palace.  After the First Court, there is the Second Court which contains the palace buildings. It is entered through a monumental gate called Bab'us-Selam or the Middle Gate.
The buildings in this court form the outer section of the palace which is called Birun. On the right there are the instantly noticed palace kitchens with their domes and chimneys and the dormitories of those who worked there. The most important of the buildings on the left side of the court are the Kubbealtı and the Inner Treasury. Behind Kubbealtı rises the Justice Tower, which is one of the symbols of the Topkapı Palace.The Harem section, which comes all the way to the back of these buildings is entered from the Third Court. Third Court is entered through the gate called Bab'üs Sa'ade (Gate of the White Eunuiches). This section of the palace is called Enderun, and it is the section where the sultans live with their extended families. Hence it is specially protected.